Basic Opioid Pharmacology
نویسندگان
چکیده
منابع مشابه
Basic opioid pharmacology: an update.
Opioids are a group of analgesic agents commonly used in clinical practice. There are three classical opioid receptors (DOP, KOP and MOP), while the novel NOP receptor is considered to be a non-opioid branch of the opioid receptor family. Opioids can act at these receptors as agonists, antagonists or partial agonists. Opioid agonists bind to G-protein coupled receptors to cause cellular hyperpo...
متن کاملOpioid pharmacology.
BACKGROUND Mu agonists have been an important component of pain treatment for thousands of years. The usual pharmacokinetic parameters (half-life, clearance, volume of distribution) of opioids have been known for some time. However, the metabolism has, until recently, been poorly understood, and there has been recent interest in the role of metabolites in modifying the pharmacodynamic response ...
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Pain is an unpleasant sensation that originates from ongoing or impending tissue damage. Management of different types of pain (acute, postoperative, inflammatory, neuropathic cancer) is challenging and yet the most frequent issue encountered by clinicians. Pharmacological therapy is the first line of approach for the treatment of pain and opioid drugs are prescribed for acute and chronic pain ...
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Introduction The science of pharmacology is concerned with the effects of drugs on the function of living tissues (Greek: Pharmakos = drug, Logos = study). Since modern medicine relies heavily on drugs as the principal tool for the treatment and prevention of disease, it is important that all clinicians possess a basic understanding of the pharmacological principles that govern their clinical u...
متن کاملThe Basic Pharmacology of Opioids Informs the Opioid Discourse about Misuse and Abuse: A Review
Morphine and other opioids are widely used to manage moderate to severe acute pain syndromes, such as pain associated with trauma or postoperative pain, and they have been used to manage chronic pain, even chronic nonmalignant pain. However, recent years have seen a renewed recognition of the potential for overuse, misuse, and abuse of opioids. Therefore, prescribing opioids is challenging for ...
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ژورنال
عنوان ژورنال: Reviews in Pain
سال: 2008
ISSN: 2042-1249
DOI: 10.1177/204946370800100202